Xiaflex Injection for Lipoma Treatment

Xiaflex Injection for Lipoma Treatment

Lipoma Clinical TrialXiaflex® (collagenase clostridium histolyticum or CCH) is currently being tested in a Phase II clinical trial in 2 locations in the US (See Trial Details: Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma)

It is the hope that collagenase injection into a lipoma will break down the collagen capsule that surrounds the lipoma and help to reduce the size of the lipoma and maybe even prevent it from growing and larger. These trials are meant to test the efficacy and efficient of this drug on lipomas (marketed under brand name Xiaflex®).

To date, the trial is still recruiting so if you live in the New York or Tennessee areas you could contact the trial coordinators and sign-up if you qualify. Last week I tried to contact the company via their forums to see if they are still recruiting but have not yet gotten an answer (company forum)

Dupuytrens contracture
Source: Wikipedia

Collagenase clostridium histolyticum or CCH is an enzyme that breaks down collagen. It is produced by a bacterium called Clostridium histolyticum and this bacteria has the ability to break down collagen. The drug is primarily being used to treat a condition called Dupuytren’s contracture, which is a condition that causes the figures to bend into the palm of the hands making it hard to straighten them. The company responsible for the development of Collagenase clostridium histolyticum (Xiaflex) is BioSpecifics Technologies, but the companies responsible for the manufacturing and marketing of the drug is actually Auxilium Pharmaceuticals and Pfizer depending on the location (US or EU).

Xiaflex was approved by the FDA in 2010 for treatment of Dupuytren’s contracture in the US. You can find some informative reviews on the Xiaflex on WebMD.

Web MD also contains information on Uses, Side Effects and Precautions as well as Dosing information.

If you would like to enroll your dog in a collagenase clinical trial, there is one currently enrolling in Carlsbad, California and you can find the details here.

Collagenase injection provides hopes for people and pets with lipomas as an alternative (non-intrusive) form of treatment. If successful, it may provide an effective way to treating multiple lipomas throughout the body where surgery is often not a viable solution due to cost and scaring.

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Collagenase Histolyticum (XIAFLEX) trial in the Treatment of Lipoma (Recruiting)

Looking to get your lipoma’s removed for free?

Lipoma Clinical TrialA double-blind study to evaluate the efficacy of collagenase histolyticum (XIAFLEX) in the treatment of lipoma is currently undergoing recruitment in the Long Island New York and Nashville Tennessee areas. If you live in or around these areas it might be a good idea to look at the trial and see if you qualify.

The goal of this trial is to see whether collagenase histolyticum is an effective agent in reducing the surface area of subcutaneous benign lipomas. The primary outcome measure is to reduce the size of the visible surface area of the lipoma within 6 months of the collagenase injection. You will also be given a questionnaire to assess satisfaction with treatment for both collagenase and placebo injections into the lipoma.

The study is designed to satisfy FDA requirements for safety and efficacy of approved drug (XIAFLEX) in the treatment of lipoma (fatty tumors). Lipomas are made up of normal fatty tissue (adipose tissue) but unlike normal fat they are encapsulated with a “balloon-like” structure composed of collagen (fibrous tissue – Watch this video). XIAFLEX, which is a protein that breaks down collagen is thought to dissolve the balloon-like structure and in turn decreasing the size of the lipoma or removing it completely.

To qualify, you need to have at least two lipomas; one for the placebo and one for the drug. Both will be observed for changes throughout the trial. You need to also be between the ages of 18 and 75, healthy, can be any race, and either sex.  Probably the hardest criteria to satisfy is that your lipomas need to be at least 5cm squared (I do not think this equals the diameter, it means surface area), and each lipoma needs to be on distinctly different parts of the body (or on torso if 30cm apart).

There is also an extensive list of exclusion criteria which you should check out to see if you quality. You can find the trial details here. If you do end up participating, please let us know and come back and comment below!

Company behind the Trial: BioSpecifics Technologies Corp. is a biopharmaceutical company that has developed injectable collagenase for twelve clinical indications to date: http://www.biospecifics.com/