Xiaflex Injection for Lipoma Treatment

Xiaflex Injection for Lipoma Treatment

Lipoma Clinical TrialXiaflex® (collagenase clostridium histolyticum or CCH) is currently being tested in a Phase II clinical trial in 2 locations in the US (See Trial Details: Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma)

It is the hope that collagenase injection into a lipoma will break down the collagen capsule that surrounds the lipoma and help to reduce the size of the lipoma and maybe even prevent it from growing and larger. These trials are meant to test the efficacy and efficient of this drug on lipomas (marketed under brand name Xiaflex®).

To date, the trial is still recruiting so if you live in the New York or Tennessee areas you could contact the trial coordinators and sign-up if you qualify. Last week I tried to contact the company via their forums to see if they are still recruiting but have not yet gotten an answer (company forum)

Dupuytrens contracture
Source: Wikipedia

Collagenase clostridium histolyticum or CCH is an enzyme that breaks down collagen. It is produced by a bacterium called Clostridium histolyticum and this bacteria has the ability to break down collagen. The drug is primarily being used to treat a condition called Dupuytren’s contracture, which is a condition that causes the figures to bend into the palm of the hands making it hard to straighten them. The company responsible for the development of Collagenase clostridium histolyticum (Xiaflex) is BioSpecifics Technologies, but the companies responsible for the manufacturing and marketing of the drug is actually Auxilium Pharmaceuticals and Pfizer depending on the location (US or EU).

Xiaflex was approved by the FDA in 2010 for treatment of Dupuytren’s contracture in the US. You can find some informative reviews on the Xiaflex on WebMD.

Web MD also contains information on Uses, Side Effects and Precautions as well as Dosing information.

If you would like to enroll your dog in a collagenase clinical trial, there is one currently enrolling in Carlsbad, California and you can find the details here.

Collagenase injection provides hopes for people and pets with lipomas as an alternative (non-intrusive) form of treatment. If successful, it may provide an effective way to treating multiple lipomas throughout the body where surgery is often not a viable solution due to cost and scaring.

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The Importance of an Accurate Lipoma Diagnosis

The Importance of an Accurate Lipoma Diagnosis

Simone Youngman Lipoma to CancerA heart-felt and inspiring story this month of 14 year-old Simone Youngman on chroniclelive.co.uk demonstrates the importance of an accurate diagnosis for lipoma. You see, not all lumps growing under the skin are lipomas. Although lipoma is the most common soft-tissue benign tumor in humans (Scientific reference), there are many other types of tumors that can grow under the skin and resemble a lipoma. For example, a Sarcoma is quite rare but resembles a lipoma, which can develop into an aggressive and terminal cancer. Read a recent post I made on the difference between Sarcoma, Carcinoma and Lipoma.

One day, Simone noticed a lump on her side while putting on her swimming costume and told her mother. Her mother decided to take Simone immediately to the hospital, which she did. The initial “Soft” diagnosis by Simone’s doctor was a lipoma, which is a soft mass of fatty cells located under the skin and surrounded by a fibrous capsule. Lipomas are non-cancerous so at this moment there was nothing to worry about. However, to be sure Simone’s doctor referred her to a specialist for an ultrasound to get an accurate lipoma diagnosis. The results from the ultrasound were also inconclusive and Simone underwent further testing in the form of a MRI scan and a biopsy.

Simone was ultimately diagnosed with undifferentiated soft tissue sarcoma. Soft tissue sarcomas arise from tissues such as fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues. They can appear anywhere on the body but most are found on the arms and legs, and less commonly on trunk, head, neck, internal organs or abdominal cavity. Sarcomas are relatively rare compared to the much more common carcinomas, which are derived from epithelial cells.

Four to five weeks later, results showed that Simone had cancer and needed urgent medical treatment. She started an aggressive course of chemotherapy followed by an operation to remove the tumor. Fortunately, things turned out ok for Simone. But imagine she had not done any followup diagnostic tests on that suspected lipoma?

What do you think? Have you has a similar encounter?

Natural Treatments for Lipoma

Natural Treatments for Lipoma

Natural Treatments for LipomaAre you tired of the medical world ignoring you and saying that lipomas are nothing to worry about unless they are a cosmetic concern or a health risk? Are you searching for alternative treatments for treating your lipomas naturally and wanting to take charge of your health and destiny? There are many accounts of people having a lot of success influencing the size and number of lipomas on their body using natural treatments for lipoma.

Lets looks at some of the more popular choices of natural treatments and point out a few things you can do to experiment with natural alternatives to treating and preventing lipomas.

Apricot Seeds (Apricot kernels)

There has been a lot of talk and literature about apricot seeds having a positive and curing effect on many cancers and tumors as well as lipomas. This is because they contain amygdalin (Laetrile).

Green Tea

A Google search will return tones of results on the effects of green tea on our health. Green tea has been shown to help in suppressing tumor growth and contains many compounds that can have positive effects on our health. It’s easy to prepare a delicious to drink! So start drinking green tea daily.


Chickweed contains compounds call saponins that help to breaks down fatty tissue. Chickweed is very easy to buy for any pharmacy and can purchased in ointment, oil or powder form depending on how you want to apply it. Try all 3 methods starting with chickweed ointment applied directly on the lipoma. Follow instructions on the bottle.

Lemons (and other citric fruits)

Lemons and any other related citric fruits (grapefruit for example) contains citric acid and are full of antioxidants that stimulate liver to do its work and destroy toxins (detoxify the body). They also stimulate fat burning and help reduce fat storage which could be beneficial to getting rid of lipomas since they are made up of fat.


Turmeric is very rich in antioxidants that slow inflammation and the formation of fat cells. Turmeric should be mixed with olive oil in a 1:1 ratio and applied daily to the lipoma.

Flaxseed Oil

Flaxseed is rich in omega-3 acids that help to dissolve fatty tissue. Apply flaxseed oil directly on to the lipoma daily.

Indian Neem

Neem is an Indian herb used in cooking. It helps break down internal fat and many have praised it for its effect of treating lipomas.

Essential Oils

There are many essential oils that can help in treating lipomas that have gotten some attention over the years. Some of these essential oils are: Ginger, Grapefruit, Clove, Frankincense, Cinnamon, Thyme,Peppermint, Eucalyptus, Lavendar, Mint, Onion and Oregano. Some time back we wrote a post on this topic you can find here: Essential Oils That Can Dissolve Lipomas

Many have expressed much success with some or a combination of the above natural lipoma treatments. They are worth a try for anyone wanting to decrease the size and number of lipomas and take preventative measures in combating the onset of lipomas. It is also worth mentioning that the list is much more extensive than the compounds listed above. The ones listed above seem to make it to the top of most of the references that can be found online and quoted by industry experts.

Lipoma Treatment and Insurance Coverage

Lipoma Treatment and Insurance CoverageAn interesting and often overlooked topic is – Do insurance companies cover lipoma removal procedures? These procedures can be costly, especially if you have multiple lipomas to remove. The short answer is that if the lipoma is being removed for cosmetic reason, your insurance company may not cover it. So before approaching you doctor to remove a lipoma, check to see if you are covered by your insurer. You may want to craft your resin for the surgery according to your insurers guidelines and coverage.

Almost all insurers will cover lipoma removal if it is due to health complications such as pain, restriction of movement, infection or any health related complication. It’s important to note that most cases where lipomas are surgically removed are for cosmetic reasons. So insurance companies are usually wary of fraudulent claims that may come in for lipoma surgery. It’s best to talk to your doctor and get your doctor’s advice on how to proceed.

Removal of a lipoma is often quite simple if the lipoma is small and easy to access. The operation is usually done on an outpatient basis under local anesthetic. A small incision is made on the skin over the lipoma and the lipoma is literally squeezed out like a pimple. If the lipoma is in a difficult to reach place or close to sensitive organs and structures like the spin or neck, the surgery maybe much more complicated and require planning and a followup appointment.