Xiaflex Injection for Lipoma Treatment
Xiaflex® (collagenase clostridium histolyticum or CCH) is currently being tested in a Phase II clinical trial in 2 locations in the US (See Trial Details: Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma)
It is the hope that collagenase injection into a lipoma will break down the collagen capsule that surrounds the lipoma and help to reduce the size of the lipoma and maybe even prevent it from growing and larger. These trials are meant to test the efficacy and efficient of this drug on lipomas (marketed under brand name Xiaflex®).
To date, the trial is still recruiting so if you live in the New York or Tennessee areas you could contact the trial coordinators and sign-up if you qualify. Last week I tried to contact the company via their forums to see if they are still recruiting but have not yet gotten an answer (company forum)
Collagenase clostridium histolyticum or CCH is an enzyme that breaks down collagen. It is produced by a bacterium called Clostridium histolyticum and this bacteria has the ability to break down collagen. The drug is primarily being used to treat a condition called Dupuytren’s contracture, which is a condition that causes the figures to bend into the palm of the hands making it hard to straighten them. The company responsible for the development of Collagenase clostridium histolyticum (Xiaflex) is BioSpecifics Technologies, but the companies responsible for the manufacturing and marketing of the drug is actually Auxilium Pharmaceuticals and Pfizer depending on the location (US or EU).
Web MD also contains information on Uses, Side Effects and Precautions as well as Dosing information.
If you would like to enroll your dog in a collagenase clinical trial, there is one currently enrolling in Carlsbad, California and you can find the details here.
Collagenase injection provides hopes for people and pets with lipomas as an alternative (non-intrusive) form of treatment. If successful, it may provide an effective way to treating multiple lipomas throughout the body where surgery is often not a viable solution due to cost and scaring.
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